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Article

PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression.

Nature communications - 16 Dec 2019

Lang Yaw-Dong, Chen Hsin-Yi, Ho Chun-Ming, Shih Jou-Ho, Hsu En-Chi, Shen Roger, Lee Yu-Ching, Chen Jyun-Wei, Wu Cheng-Yen, Yeh Hsi-Wen, Chen Ruey-Hwa, Jou Yuh-Shan

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to metastasis. Paraspeckle component 1 (PSPC1) upregulation has been identified as an HCC pro-metastatic activator associated with poor patient prognosis, but with a lack of targeting strategy. Here, we report that PSPC1, a nuclear substrate of PTK6, sequesters PTK6 in the nucleus and loses its metastasis driving capability....

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Identifiers

PMID: 31844057
DOI: 10.1038/s41467-019-13665-6
PMCID: PMC6914800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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