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Article

STOP gene Phactr4 is a tumor suppressor.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jan 2013

Solimini Nicole L, Liang Anthony C, Xu Chunxiao, Pavlova Natalya N, Xu Qikai, Davoli Teresa, Li Mamie Z, Wong Kwok-Kin, Elledge Stephen J

Abstract excerpt

Cancer develops through genetic and epigenetic alterations that allow unrestrained proliferation and increased survival. Using a genetic RNAi screen, we previously identified hundreds of suppressors of tumorigenesis and/or proliferation (STOP) genes that restrain normal cell proliferation. Our STOP gene set was significantly enriched for known and putative tumor suppressor genes. Here, we report a...

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Identifiers

PMID: 23319639
DOI: 10.1073/pnas.1221385110
PMCID: PMC3562831

Genes

PHACTR4

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