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Article

Drosophila happyhour modulates JNK-dependent apoptosis.

Cell death & disease - 19 Aug 2010

Lam D, Shah S, de Castro I P, Loh S H Y, Martins L M

Abstract excerpt

Mitogen-activated protein kinase kinase kinase kinase-3 (MAP4K3) is a Ste20 kinase family member that modulates multiple signal transduction pathways. We recently identified MAP4K3 as proapoptotic kinase using an RNA interference screening approach. In mammalian cells, MAP4K3 enhances the mitochondrial apoptosis pathway through the post-transcriptional modulation of selected proapoptotic Bcl-2 homology domain...

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Identifiers

PMID: 21364671
DOI: 10.1038/cddis.2010.44
PMCID: PMC3032524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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