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Article

Analysis of Trans-Ancestral SLE Risk Loci Identifies Unique Biologic Networks and Drug Targets in African and European Ancestries.

American journal of human genetics - 5 Nov 2020

Owen Katherine A, Price Andrew, Ainsworth Hannah, Aidukaitis Bryce N, Bachali Prathyusha, Catalina Michelle D, Dittman James M, Howard Timothy D, Kingsmore Kathryn M, Labonte Adam C, Marion Miranda C, Robl Robert D, Zimmerman Kip D, Langefeld Carl D, Grammer Amrie C, Lipsky Peter E

Abstract excerpt

Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with a prominent genetic component. Individuals of African ancestry (AA) experience the disease more severely and with an increased co-morbidity burden compared to European ancestry (EA) populations. We hypothesize that the disparities in disease prevalence, activity, and response to standard medications between AA and EA populations is...

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Identifiers

PMID: 33031749
DOI: 10.1016/j.ajhg.2020.09.007
PMCID: PMC7675009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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