Article
Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing.
Annals of the rheumatic diseases - 1 Jan 2021
Sandling Johanna K, Pucholt Pascal, Hultin Rosenberg Lina, Farias Fabiana H G, Kozyrev Sergey V, Eloranta Maija-Leena, Alexsson Andrei, Bianchi Matteo, Padyukov Leonid, Bengtsson Christine, Jonsson Roland, Omdal Roald, Lie Benedicte A, Massarenti Laura, Steffensen Rudi, Jakobsen Marianne A, Lillevang Søren T, Lerang Karoline, Molberg Øyvind, Voss Anne, Troldborg Anne, Jacobsen Søren, Syvänen Ann-Christine, Jönsen Andreas, Gunnarsson Iva, Svenungsson Elisabet, Rantapää-Dahlqvist Solbritt, Bengtsson Anders A, Sjöwall Christopher, Leonard Dag, Lindblad-Toh Kerstin, Rönnblom Lars
Abstract excerpt
OBJECTIVES: Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive heterogeneity in disease presentation between patients, which is likely due to an underlying molecular diversity. Here, we aimed at elucidating the genetic aetiology of SLE from the immunity pathway level to the single variant level, and stratify patients with SLE into distinguishable molecular subgroups, which could inform...
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