Article

The <i>E. coli</i> CNF1 toxin induces fetal reprogramming of intestinal stem cells and a serrated colorectal cancer transcriptional signature in organoids

2025-10-04

Abstract excerpt

<h4>SUMMARY</h4> Mechanistic insights are essential to understand how gut microbiota pathobionts contribute to tumorigenesis, given the mounting evidence linking them to colorectal cancer. We report a higher prevalence of the Rho GTPases-targeting cnf1 toxin gene from Escherichia coli in the microbiota of early-stage, proximal colorectal cancer. Comparative gene set enrichment analysis reveals a concordant serr...

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Literature Corpus work: 25dbecb2-1090-5c8f-b036-375529f4d2f5
DOI: 10.1101/2025.10.02.680056

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