Article
High-Fidelity Profiling of Multiple Nearby Mutations via Cooperative Recognition.
Angewandte Chemie (International ed. in English) - 13 Oct 2025
Xia Xuhan, Yang Hao, Zeng Zhen, He Ruonan, Zhu Xianglin, Zhang Yong, Lin Feng, Deng Ruijie, Li Feng
Abstract excerpt
Detection methods with single-nucleotide specificity are essential tools for nucleic acid analysis in diverse clinical and biological settings. However, both hybridization-based and enzyme-based methods are only effective for discriminating single-nucleotide mutations at certain positions, making it difficult to detect nucleic acid targets having multiple nearby mutations. Herein, we describe the design of...
Topics
- Humans
- Mutation
- Nucleic Acid Hybridization
- MicroRNAs
- Polymorphism, Single Nucleotide