High-Fidelity Profiling of Multiple Nearby Mutations via Cooperative Recognition.

Abstract excerpt

Detection methods with single-nucleotide specificity are essential tools for nucleic acid analysis in diverse clinical and biological settings. However, both hybridization-based and enzyme-based methods are only effective for discriminating single-nucleotide mutations at certain positions, making it difficult to detect nucleic acid targets having multiple nearby mutations. Herein, we describe the design of...

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