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Article

A universal probe design for colorimetric detection of single-nucleotide variation with visible readout and high specificity.

Scientific reports - 2 Feb 2016

Chen Xueping, Zhou Dandan, Shen Huawei, Chen Hui, Feng Wenli, Xie Guoming

Abstract excerpt

Single-nucleotide variation (SNV) is a crucial biomarker for drug resistance-related detection in cancer and bacterial infection. However, the unintended binding of DNA probes limits the specificity of SNV detection, and the need for redesigned sequences compromise the universality of SNV assay. Herein, we demonstrated a universal and low-cost assay for the colorimetric discrimination of drug-resistance related...

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Identifiers

PMID: 26830326
DOI: 10.1038/srep20257
PMCID: PMC4735751

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EGFR
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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