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Article

Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation.

The Journal of biological chemistry - 2 Sept 2005

Bertoncini Carlos W, Fernandez Claudio O, Griesinger Christian, Jovin Thomas M, Zweckstetter Markus

Abstract excerpt

A30P and A53T mutations of the presynaptic protein alpha-synuclein are associated with familial forms of Parkinson disease. NMR spectroscopy demonstrates that Parkinsonism-linked mutations greatly perturb specific tertiary interactions essential for the native state of alpha-synuclein. However, a...

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Identifiers

PMID: 16020550
DOI: 10.1074/jbc.C500288200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16020550-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation.PMID 16020550Read ↗

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