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Article

Molecular Pathogenesis of Mantle Cell Lymphoma.

Hematology/oncology clinics of North America - 1 Oct 2020

Navarro Alba, Beà Sílvia, Jares Pedro, Campo Elías

Abstract excerpt

Mantle cell lymphoma (MCL) is a mature B-cell neoplasm with heterogeneous clinical behavior molecularly characterized by the constitutive overexpression of cyclin D1 and deregulation of different signaling pathways. SOX11 expression determines an aggressive phenotype associated with accumulation of many chromosomal alterations and somatic gene mutations. A subset of patients with the SOX11-negative leukemic...

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Share to Chronic Lymphocytic Leukemia Research
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32861278
DOI: 10.1016/j.hoc.2020.05.002
PMCID: PMC7473344

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