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Article

SOX11 augments BCR signaling to drive MCL-like tumor development.

Blood - 17 May 2018

Kuo Pei-Yu, Jatiani Shashidhar S, Rahman Adeeb H, Edwards Donna, Jiang Zewei, Ahr Katya, Perumal Deepak, Leshchenko Violetta V, Brody Joshua, Shaknovich Rita, Ye B Hilda, Parekh Samir

Abstract excerpt

Mantle cell lymphoma (MCL) is characterized by increased B-cell receptor (BCR) signaling, and BTK inhibition is an effective therapeutic intervention in MCL patients. The mechanisms leading to increased BCR signaling in MCL are poorly understood, as mutations in upstream regulators of BCR signaling such as CD79A, commonly observed in other lymphomas, are rare in MCL. The transcription factor SOX11 is...

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Topics

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Share to B-Lymphocytes
Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to High-Throughput Nucleotide Sequencing

Share to Immunoglobulin Heavy Chains

Share to Lymphoma, Mantle-Cell

Share to Receptors, Antigen, B-Cell

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 29615403
DOI: 10.1182/blood-2018-02-832535
PMCID: PMC5958658

Genes

SOX11
BCR
BTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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