Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distribution analysis of nonsynonymous polymorphisms within the human kinase gene family.

Genomics - 1 Jul 2007

Torkamani Ali, Schork Nicholas J

Abstract excerpt

The human kinase gene family is composed of 518 genes that are involved in a diverse spectrum of physiological functions. They are also implicated in a number of diseases and encompass 10% of current drug targets. Contemporary, high-throughput sequencing efforts have identified a rich source of naturally occurring single nucleotide polymorphisms (SNPs) in kinases, a subset of which occur in the coding region of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Databases, Genetic
Share to Multigene Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphotransferases

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 17498919
DOI: 10.1016/j.ygeno.2007.03.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distribution analysis of nonsynonymous polymorphisms within the human kinase gene family.PMID 17498919Read ↗

Accurate prediction of deleterious protein kinase polymorphisms.Semantic proximity Read ↗

Predisposing deleterious variants in the cancer-associated human kinases in the global populations.Semantic proximity Read ↗

Kinase mutations in human disease: interpreting genotype-phenotype relationships.Semantic proximity Read ↗

Cancer-associated mutations are preferentially distributed in protein kinase functional sites.Semantic proximity Read ↗

Congenital disease SNPs target lineage specific structural elements in protein kinases.Semantic proximity Read ↗

A survey of the population genetic variation in the human kinome.Semantic proximity Read ↗

Discriminating activating, deactivating and resistance variants in protein kinasesSemantic proximity Read ↗

Sequence and structure signatures of cancer mutation hotspots in protein kinases.Semantic proximity Read ↗

Deleterious single nucleotide polymorphisms of protein kinase R identified by the computational approach.Semantic proximity Read ↗

KinMutBase: a registry of disease-causing mutations in protein kinase domains.Semantic proximity Read ↗

In silico functional profiling of human disease-associated and polymorphic amino acid substitutions.Semantic proximity Read ↗

PhosSNP for systematic analysis of genetic polymorphisms that influence protein phosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.