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Prediction of Deleterious Non-synonymous SNPs of Human STK11 Gene by Combining Algorithms, Molecular Docking, and Molecular Dynamics Simulation.

Scientific reports - 11 Nov 2019

Islam Md Jahirul, Khan Akib Mahmud, Parves Md Rimon, Hossain Md Nayeem, Halim Mohammad A

Abstract excerpt

Serine-threonine kinase11 (STK11) is a tumor suppressor gene which plays a key role in regulating cell growth and apoptosis. It is widely known as a multitasking kinase and engaged in cell polarity, cell cycle arrest, chromatin remodeling, energy metabolism, and Wnt signaling. The substitutions of single amino acids in highly conserved regions of the STK11 protein are associated with Peutz-Jeghers syndrome (PJS),...

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PMID: 31712642
DOI: 10.1038/s41598-019-52308-0
PMCID: PMC6848484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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