Article
CXCL4-Induced PBMCs Modulate Vascular Extracellular Matrix via Wnt5a-Dependent Matrix Metalloproteinase-7 and Calcifying Extracellular Vesicle Release.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2025
Krohn Jona B, Sprehe Laurine Kristin, Sicklinger Florian, Kawohl Julie, Hess Chiara, Spieler Anja, Dihlmann Susanne, Eis Larissa, Gleissner Christian A, Katus Hugo A, Frey Norbert, Leuschner Florian
Abstract excerpt
BACKGROUND: The role of macrophage heterogeneity has become increasingly well-recognized in the study of vascular inflammatory responses. The CXCL4 (chemokine [C-X-C motif] ligand 4)-induced monocyte/macrophage phenotype has been implicated in atherosclerotic plaque destabilization, a key process preceding plaque rupture. Monocyte-derived macrophages differentiated with CXCL4 exhibit a unique transcriptome...
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