Article

Patient-Derived Circulating Monocytes Promote Calcific Aortic Valve Disease Progression

2026-05-04

Abstract excerpt

<h4>Background</h4> Calcific aortic valve disease (CAVD) is the most common valvular heart disease in developed countries, yet no pharmacological therapy is available to slow or halt its progression. CAVD is driven by progressive calcification of aortic valve leaflets, in which myeloid cells play a central role. While macrophages have been implicated in CAVD pathogenesis, the contribution of their precursors, mon...

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Literature Corpus work: df0a9af7-4ef9-5ede-88cb-00044606d563
DOI: 10.64898/2026.04.30.721898

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