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Article

Two-faced Janus: the dual role of macrophages in atherosclerotic calcification

20 Sept 2021

Abstract excerpt

Calcification is an independent predictor of atherosclerosis-related cardiovascular events. Microcalcification is linked to inflamed, unstable lesions, in comparison to the fibrotic stable plaque phenotype generally associated with advanced calcification. This paradox relates to recognition that calcification presents in a wide spectrum of manifestations that differentially impact plaque's fate. Macrophages, the...

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PMID: 34550346
DOI: 10.1093/cvr/cvab301

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