Article
Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2016
Krohn Jona B, Hutcheson Joshua D, Martínez-Martínez Eduardo, Irvin Whitney S, Bouten Carlijn V C, Bertazzo Sergio, Bendeck Michelle P, Aikawa Elena
Abstract excerpt
OBJECTIVE: Collagen accumulation and calcification are major determinants of atherosclerotic plaque stability. Extracellular vesicle (EV)-derived microcalcifications in the collagen-poor fibrous cap may promote plaque rupture. In this study, we hypothesize that the collagen receptor discoidin domain receptor-1 (DDR-1) regulates collagen deposition and release of calcifying EVs by vascular smooth muscle cells...
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