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Identification of key regulators for the migration and invasion of rheumatoid synoviocytes through a systems approach

27 Dec 2013

Abstract excerpt

Rheumatoid synoviocytes, which consist of fibroblast-like synoviocytes (FLSs) and synovial macrophages (SMs), are crucial for the progression of rheumatoid arthritis (RA). Particularly, FLSs of RA patients (RA-FLSs) exhibit invasive characteristics reminiscent of cancer cells, destroying cartilage and bone. RA-FLSs and SMs originate differently from mesenchymal and myeloid cells, respectively, but share many...

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PMID: 24374632
DOI: 10.1073/pnas.1311239111

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