Article

Immunological Profiling in Knee Osteoarthritis: Treg Dysfunction as Key Driver of Pain

2024-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Pain is the hallmark symptom of osteoarthritis (OA) and its biological drivers remain poorly understood. While the role of innate immunity in OA has been extensively studied, the involvement of adaptive immunity, in particular regulatory T cells (Tregs), is not well understood. Using a comprehensive multi-omic approach on the peripheral blood from 46 knee OA patients with similar radiographic st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 137d5488-465b-5c49-9892-affdac8bc219
DOI: 10.1101/2024.10.12.618016

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunological Profiling in Knee Osteoarthritis: Treg Dysfunction as Key Driver of PainDOI 10.1101/2024.10.12.618016Read

Molecular and spatial profiling identifies immune endotypes for the stratification of OA patientsSemantic proximity Read

Identification of osteoarthritis-characteristic genes and immunological micro-environment features through bioinformatics and machine learning-based approachesSemantic proximity Read

Identification of immune microenvironment subtypes and clinical risk biomarkers for osteoarthritis based on a machine learning modelSemantic proximity Read

Identification of osteoarthritis-characteristic genes and immunological micro-environment features by bioinformatics and machine learningSemantic proximity Read

Human regulatory T-cells locally differentiate and are functionally heterogeneous within the inflamed arthritic jointSemantic proximity Read

Gene Dysregulation in Peripheral Blood of Young Females With Temporomandibular Joint OsteoarthritisSemantic proximity Read

Causal associations between circulating immune cells and osteoarthritis: A bidirectional mendelian randomization studySemantic proximity Read

Generation of a T cell receptor, cytokine and cell repertoire synovial fluid atlas to define commonalities and dissimilarities between arthritic diseases through systems immunology approachesSemantic proximity Read

Chondrocytes from Osteoarthritis Patients Adopt Distinct Phenotypes in Response to Central TH1/TH2/TH17 Cytokines.Semantic proximity Read

The Immune Cell Landscape in Different Anatomical Structures of Knee in Osteoarthritis: A Gene Expression‐Based StudySemantic proximity Read

Multiparametric Profiling of Circulating Immune Cells Identifies an Expansion of CD25high Switched Memory B Cells in OsteoarthritisSemantic proximity Read

Screening of diagnostic markers related to immune infiltration in osteoarthritis patients based on machine learningSemantic proximity Read