Article

Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis

2023-10-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Synovium is home to immune and stromal cell types that orchestrate inflammation following a joint injury; in particular, macrophages are central protagonists in this process. We sought to define the cellular and temporal dynamics of the synovial immune niche in a mouse model of post-traumatic osteoarthritis (PTOA), and to identify stromal-immune crosstalk mechanisms that coor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6aadf93-9aab-5198-a7ff-c24d7ce2366a
DOI: 10.1101/2023.10.03.559514

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritisDOI 10.1101/2023.10.03.559514Read

Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritisSemantic proximity Read

Modulating Inflammation in Post-Traumatic Osteoarthritis using iPSC-derived Anti-inflammatory MacrophagesSemantic proximity Read

Monocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis?Semantic proximity Read

Immunotherapy with Pro-regenerative Macrophages from Embryonic Stem Cells Ameliorate Osteoarthritis via TNFAIP3-Mediated ChondroprotectionSemantic proximity Read

Macrophages drive the inflammatory phase in experimental osteoarthritisSemantic proximity Read

Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injurySemantic proximity Read

Monocyte‐Derived Macrophages‐Synovial Fibroblasts Crosstalk Unravels Oncostatin Signaling Network as a Driver of Synovitis in OsteoarthritisSemantic proximity Read

Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patientsSemantic proximity Read

CD34hi subset of synovial fibroblasts contributes to fibrotic phenotype of human knee osteoarthritis.Semantic proximity Read

Macrophages regulate the progression of osteoarthritis.Semantic proximity Read

Synovial Macrophages in Osteoarthritis: The Key to Understanding Pathogenesis?Semantic proximity Read

Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritisSemantic proximity Read