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Article

sIL-6R impact on aortic aneurysm: Genetic evidence from FinnGen and GWAS.

International journal of cardiology - 15 Dec 2025

Wang Mengmeng, Teng Tianqi, Mo Degang, Zhang Nan, Chen Rui, Xu Jiachao, Dong Zihan, Zhang Ning, Yu Haichu

Abstract excerpt

BACKGROUND: The causal relationship between soluble interleukin-6 receptor (sIL-6R) and the risk of aortic aneurysm (AA) is unclear. This study used a two-sample Mendelian randomization (MR) approach, utilizing FinnGen and GWAS data, to investigate the potential causal link between sIL-6R and AA risk. METHODS: A two-phase study was conducted to comprehensively assess potential causal relationships. In the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40819721
DOI: 10.1016/j.ijcard.2025.133786

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