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Article

Genetic causal association between lipidomic profiles, inflammatory proteomics, and aortic stenosis: a Mendelian randomization investigation.

European journal of medical research - 31 Aug 2024

Zhu Linwen, Li Ni, Shi Huoshun, Shao Guofeng, Sun Lebo

Abstract excerpt

BACKGROUND: Aortic stenosis (AS) is a prevalent and serious valvular heart disease with a complex etiology involving genetic predispositions, lipid dysregulation, and inflammation. The specific roles of lipid and protein biomarkers in AS development are not fully elucidated. This study aimed to elucidate the causal relationships between lipidome, inflammatory proteins, and AS using Mendelian randomization (MR),...

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Identifiers

PMID: 39217396
DOI: 10.1186/s40001-024-02014-z
PMCID: PMC11365128

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