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Article

A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity

20 Sept 2019

Abstract excerpt

Abstract Growing evidence suggests that inflammation is a significant contributor to different cardiovascular diseases (CVDs). Mendelian randomization (MR) was performed to assess the causal inference between plasma soluble IL6 receptor (sIL6R), a negative regulator of IL6 signaling, and different cardiovascular and immune-related disorders.Cis-MR with multiple instrumental variables showed an inverse association...

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PMID: 31552141
DOI: 10.1038/s41525-019-0097-4

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