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Predictive capabilities of polygenic scores in an East-Asian population-based cohort: the Singapore Chinese health study.

Communications biology - 15 Aug 2025

Chang Xuling, Shih Chih Chuan, Chen Jieqi, Lee Ai Shan, Tan Patrick, Wang Ling, Liu Jianjun, Li Jingmei, Yuan Jian-Min, Khor Chiea Chuen, Koh Woon-Puay, Dorajoo Rajkumar

Abstract excerpt

Polygenic scores (PGS) are derived primarily from European population studies. It is unclear how these perform in risk predictions among East-Asians. We generated 2173 PGSs from 519 traits and assessed their associations with 58 baseline phenotypes in the Singapore Chinese Health Study, a prospective cohort of 23,622 Chinese adults residing in Singapore. PGS performances were evaluated through explained variance...

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Identifiers

PMID: 40817126
DOI: 10.1038/s42003-025-08675-8
PMCID: PMC12356951

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