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Article

Evaluation of optimal methods and ancestries for calculating polygenic risk scores in East Asian population.

Scientific reports - 6 Nov 2023

Kim Dong Jun, Kang Joon Ho, Kim Ji-Woong, Cheon Myeong Jae, Kim Sun Bin, Lee Young Kee, Lee Byung-Chul

Abstract excerpt

Polygenic risk scores (PRSs) have been studied for predicting human diseases, and various methods for PRS calculation have been developed. Most PRS studies to date have focused on European ancestry, and the performance of PRS has not been sufficiently assessed in East Asia. Herein, we evaluated the predictive performance of PRSs for East Asian populations under various conditions. Simulation studies using data...

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Identifiers

PMID: 37932343
DOI: 10.1038/s41598-023-45859-w
PMCID: PMC10628155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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