Article
Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians.
Genome medicine - 19 Feb 2021
Tam Claudia H T, Lim Cadmon K P, Luk Andrea O Y, Ng Alex C W, Lee Heung-Man, Jiang Guozhi, Lau Eric S H, Fan Baoqi, Wan Raymond, Kong Alice P S, Tam Wing-Hung, Ozaki Risa, Chow Elaine Y K, Lee Ka-Fai, Siu Shing-Chung, Hui Grace, Tsang Chiu-Chi, Lau Kam-Piu, Leung Jenny Y Y, Tsang Man-Wo, Kam Grace, Lau Ip-Tim, Li June K Y, Yeung Vincent T F, Lau Emmy, Lo Stanley, Fung Samuel, Cheng Yuk-Lun, Chow Chun-Chung, Hu Miao, Yu Weichuan, Tsui Stephen K W, Huang Yu, Lan Huiyao, Szeto Cheuk-Chun, Tang Nelson L S, Ng Maggie C Y, So Wing-Yee, Tomlinson Brian, Chan Juliana C N, Ma Ronald C W
Abstract excerpt
BACKGROUND: The clinical utility of personal genomic information in identifying individuals at increased risks for dyslipidemia and cardiovascular diseases remains unclear. METHODS: We used data from Biobank Japan (n = 70,657-128,305) and developed novel East Asian-specific genome-wide polygenic risk scores (PRSs) for four lipid traits. We validated (n = 4271) and subsequently tested associations of these scores...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.