A ptsH mutation suppresses growth defects and antibiotic sensitivity in a cpgA mutant defective in metabolite proofreading.

doi:10.1128/jb.00162-25

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Article

A ptsH mutation suppresses growth defects and antibiotic sensitivity in a cpgA mutant defective in metabolite proofreading.

Journal of bacteriology - 18 Sept 2025

Sachla Ankita J, Gaballa Ahmed, Herrera Diana, Helmann John D

Abstract excerpt

Bacillus subtilis CpgA (circularly permuted GTPase) is a ribosome assembly GTPase that has a secondary function as a metabolite proofreading enzyme. CpgA hydrolyzes 4-phosphoerythronate, a toxic metabolite produced from erythrose-4-phosphate by glyceraldehyde-3-phosphate dehydrogenase (GAPDH). In a ∆cpgA strain, carbon sources that feed into the pentose phosphate pathway trigger metabolic intoxication. This...

Topics

Anti-Bacterial Agents
Bacterial Proteins
Bacillus subtilis
Phosphoenolpyruvate Sugar Phosphotransferase System
Glucose
Mutation
Gene Expression Regulation, Bacterial
Gluconates

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Identifiers

PMID: 40810512
DOI: 10.1128/jb.00162-25
PMCID: PMC12445079

Genes

GAPDH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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