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Article

Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity.

mBio - 9 Apr 2025

She Fukang, Liu Kuanqing, Anderson Brent W, Pisithkul Tippapha, Li Yanxiu, Fung Danny K, McCue Tyler, Mulhern William, Amador-Noguez Daniel, Wang Jue D

Abstract excerpt

Guanosine triphosphate (GTP) is essential for macromolecular biosynthesis, and its intracellular levels are tightly regulated in bacteria. Loss of the alarmone (p)ppGpp disrupts GTP regulation in Bacillus subtilis, causing cell death in the presence of exogenous guanosine and underscoring the critical importance of GTP homeostasis. To investigate the basis of guanosine toxicity, we performed a genetic selection...

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Identifiers

PMID: 39998177
DOI: 10.1128/mbio.03798-24
PMCID: PMC11980595

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