Loss of protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system, by mutation of the ptsH gene confers catabolite repression resistance to several catabolic genes of Bacillus subtilis.

doi:10.1128/jb.176.11.3336-3344.1994

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Article

Loss of protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system, by mutation of the ptsH gene confers catabolite repression resistance to several catabolic genes of Bacillus subtilis.

Journal of bacteriology - 1 Jun 1994

Deutscher J, Reizer J, Fischer C, Galinier A, Saier M H, Steinmetz M

Abstract excerpt

In gram-positive bacteria, HPr, a phosphocarrier protein of the phosphoenolpyruvate:sugar phosphotransferase system (PTS), is phosphorylated by an ATP-dependent, metabolite-activated protein kinase on seryl residue 46. In a Bacillus subtilis mutant strain in which Ser-46 of HPr was replaced with...

Topics

Bacillus subtilis
Bacterial Proteins
Base Sequence
Enzyme Repression
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Genes, Bacterial
Gluconates
Mannitol
Molecular Sequence Data
Monosaccharide Transport Proteins
Mutation
Phosphoenolpyruvate Sugar Phosphotransferase System

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Phosphotransferases (Alcohol Group Acceptor)

Promoter Regions, Genetic

Protein Kinases

Sorbitol

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Identifiers

PMID: 8195089
DOI: 10.1128/jb.176.11.3336-3344.1994
PMCID: PMC205505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8195089-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.