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Article

Purine limitation prevents the exogenous pyridoxal 5'-phosphate accumulation of Salmonella enterica yggS mutants.

Microbiology spectrum - 5 Dec 2024

Ezekiel Kailey S, Downs Diana M

Abstract excerpt

YggS belongs to the highly conserved pyridoxal 5'-phosphate (PLP) binding protein family (COG0325) that is found in all domains of life. Though no precise biochemical activity or molecular mechanism has been determined for this protein, an involvement in vitamin B6 homeostasis has been demonstrated in multiple organisms. In Salmonella enterica, loss of YggS results in altered B6 vitamer pools, including an...

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Identifiers

PMID: 39436136
DOI: 10.1128/spectrum.02075-24
PMCID: PMC11619424

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