Article
PhoU2 but Not PhoU1 as an Important Regulator of Biofilm Formation and Tolerance to Multiple Stresses by Participating in Various Fundamental Metabolic Processes in Staphylococcus epidermidis.
Journal of bacteriology - 15 Dec 2017
Wang Xiaofei, Han Haiyan, Lv Zhihui, Lin Zhiwei, Shang Yongpeng, Xu Tao, Wu Yang, Zhang Ying, Qu Di
Abstract excerpt
PhoU, a conserved protein that has been proposed to coordinate phosphate import, is a negative regulator of drug tolerance in most bacteria. In Staphylococcus epidermidis, the role of PhoU in biofilm formation and drug tolerance has not yet been investigated. Two PhoU homologs in the genome of S. epidermidis have been identified by the presence of the conserved motif E(D)XXXD of PhoU. We separately constructed...
Topics
- ATP Synthetase Complexes
- Anti-Bacterial Agents
- Bacterial Proteins
- Biofilms
- Citric Acid Cycle
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Hydrogen Peroxide
- Membrane Transport Proteins