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Article

Clone copy number diversity is linked to survival in lung cancer.

Nature - 1 Oct 2025

Pawlik Piotr, Grigoriadis Kristiana, Bunkum Abigail, Coggan Helena, Frankell Alexander M, Martinez-Ruiz Carlos, Karasaki Takahiro, Huebner Ariana, Rowan Andrew, Fisher Jasmin, Hackshaw Allan, Swanton Charles, Zaccaria Simone, McGranahan Nicholas

Abstract excerpt

Both single nucleotide variants (SNVs) and somatic copy number alterations (SCNAs) accumulate in cancer cells during tumour development, fuelling clonal evolution. However, accurate estimation of clone-specific copy numbers from bulk DNA-sequencing data is challenging. Here we present allele-specific phylogenetic analysis of copy number alterations (ALPACA), a method to infer SNV and SCNA coevolution by...

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Identifiers

PMID: 40804524
DOI: 10.1038/s41586-025-09398-w
PMCID: PMC12488491

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CCND1

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