Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice.

Circulation - 25 Feb 2003

Combadière Christophe, Potteaux Stéphane, Gao Ji-Liang, Esposito Bruno, Casanova Saveria, Lee Eric J, Debré Patrice, Tedgui Alain, Murphy Philip M, Mallat Ziad

Abstract excerpt

BACKGROUND: Fractalkine (CX3CL1), a CX3C chemokine, is expressed in the vessel wall and mediates the firm adhesion and chemotaxis of leukocytes expressing its receptor, CX3CR1. A polymorphism in the CX3CR1 gene is associated with low CX3CR1 expression and reduced risk of acute coronary disease in humans. METHODS AND RESULTS: We generated CX3CR1-deficient mice (CX3CR1(-/-)) by targeted gene disruption and crossed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arteriosclerosis
Share to Chemotaxis, Leukocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CX3C Chemokine Receptor 1

Share to Gene Targeting

Share to Monocytes

Share to Receptors, Chemokine

Share to Receptors, Cytokine

Share to Receptors, HIV

Source

Identifiers

PMID: 12600915
DOI: 10.1161/01.cir.0000057548.68243.42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice.PMID 12600915Read ↗

Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis.Semantic proximity Read ↗

Chemokines and atherosclerosis: focus on the CX3CL1/CX3CR1 pathway.Semantic proximity Read ↗

The role of chemokines in atherosclerosis: recent evidence from experimental models and population geneticsSemantic proximity Read ↗

Chemokine CX3CL1 and its receptor CX3CR1 are associated with human atherosclerotic lesion volnerability.Semantic proximity Read ↗

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survivalSemantic proximity Read ↗

Genetic Ablation of Caveolin-1 Confers Protection Against AtherosclerosisSemantic proximity Read ↗

Genetic silencing of K Ca 3.1 inhibits atherosclerosis in ApoE null miceSemantic proximity Read ↗

Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice.Semantic proximity Read ↗

Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Limits Progression and Destabilization of Established Atherosclerosis in Apolipoprotein E–Knockout MiceSemantic proximity Read ↗

Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice.Semantic proximity Read ↗

TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE(-/-) mice.Semantic proximity Read ↗

Overexpression of CXCL16 promotes a vulnerable plaque phenotype in Apolipoprotein E-Knockout Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.