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Article

Map3k8 Modulates Monocyte State and Atherogenesis in ApoE-/- Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2017

Sanz-Garcia Carlos, Sánchez Ángela, Contreras-Jurado Constanza, Cales Carmela, Barranquero Cristina, Muñoz Marta, Merino Ramón, Escudero Paula, Sanz Maria-Jesús, Osada Jesús, Aranda Ana, Alemany Susana

Abstract excerpt

OBJECTIVE: Map3k8 (Cot/Tpl2) activates the MKK1/2-ERK1/2, MAPK pathway downstream from interleukin-1R, tumor necrosis factor-αR, NOD-2R (nucleotide-binding oligomerization domain-like 2R), adiponectinR, and Toll-like receptors. Map3k8 plays a key role in innate and adaptive immunity and influences inflammatory processes by modulating the functions of different cell types. However, its role in atherogenesis...

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Source

Identifiers

PMID: 27856455
DOI: 10.1161/ATVBAHA.116.308528

Genes

CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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