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Article

Identification of Myeloid Protein Kinase C Epsilon as a Novel Atheroprotective Gene.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2025

Wells Alexis T, Bossardi Ramos Ramon, Shen Michelle M, Binrouf Redwan H, Swinegar Anna E, Lennartz Michelle R

Abstract excerpt

BACKGROUND: Atherosclerosis is a chronic inflammatory disease driven by macrophages. PKCɛ (protein kinase C epsilon) is a serine/threonine kinase involved in diverse cellular processes including migration, growth, differentiation, and survival. PKCɛ acts in a context-dependent manner within the heart; however, its role in atherosclerosis is unknown. METHODS: Bone marrow-derived macrophages from global PKCɛ...

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Source

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Identifiers

PMID: 40703062
DOI: 10.1161/ATVBAHA.125.323005
PMCID: PMC12364379

Genes

PRKCE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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