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Article

Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2017

Xu Rende, Li Chenguang, Wu Yizhe, Shen Li, Ma Jianying, Qian Juying, Ge Junbo

Abstract excerpt

OBJECTIVE: Emerging evidence indicates that proinflammatory macrophage polarization imbalance plays a key role in atherosclerotic plaque progression and instability. The calcium-activated potassium channel KCa3.1 is critically involved in macrophage activation and function. However, the role of KCa3.1 in macrophage polarization is unknown. This study investigates the potential role of KCa3.1 in transcriptional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28062499
DOI: 10.1161/ATVBAHA.116.308461

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