T-cell lymphoma-associated STAT3 variants impose a type 1 regulatory-like phenotype.

Abstract excerpt

STAT3 signaling is fundamental to T cells, where it underlies basic cellular processes like metabolism and apoptosis, as well as specialized processes like effector differentiation and cytokine production. However, mutations of STAT3 are strikingly prevalent in T-cell cancers, and aberrant or excessive STAT3 signaling is thought to mobilize cellular pathways that encourage malignancy. To better understand how...

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