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Article

Leader cells promote immunosuppression to drive ovarian cancer progression in vivo

1 Nov 2024

Abstract excerpt

Over 75% of patients with ovarian cancer present with late-stage disease, often accompanied by extensive metastasis. The metastatic cascade is driven by a sub-population of transcriptionally plastic cells known as "leader cells" (LCs), which play a critical role in collective invasion yet remain poorly understood. LCs are marked by the expression of keratin-14 (KRT14), which determines their migratory and...

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PMID: 39541210
DOI: 10.1016/j.celrep.2024.114979

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