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Article

MTA1 Promotes STAT3 Transcription and Pulmonary Metastasis in Breast Cancer

11 Apr 2013

Abstract excerpt

Overexpression of the prometastatic chromatin modifier protein metastasis tumor antigen 1 (MTA1) in human cancer contributes to tumor aggressiveness, but the role of endogenous MTA1 in cancer has not been explored. Here, we report the effects of selective genetic depletion of MTA1 in a physiologically relevant spontaneous mouse model of breast cancer pulmonary metastasis. We found that MTA1 acts as a mandatory...

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PMID: 23580571
DOI: 10.1158/0008-5472.can-12-3998

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