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Article

FLT3LG as an inflammatory hub bridging tumor immune surveillance to therapy response in breast cancer.

Clinical and experimental medicine - 29 Oct 2025

Lu Yun, Li Xiangyu, Chao Tengfei, Xiong Huihua, Yao Wei

Abstract excerpt

Breast cancer remains one of the most deadly cancers, highlighting the urgent need for better prognostic markers and treatment targets. Emerging evidence suggests that inflammation-driven immune dysregulation plays a pivotal role in breast cancer progression and therapy resistance. Single-cell RNA sequencing and comprehensive gene network analysis based on inflammation identified FLT3LG as a crucial protective...

Read the complete abstract on PubMed

Topics

Humans
Breast Neoplasms
Female
Biomarkers, Tumor
Membrane Proteins
Mutation
Prognosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Immunologic Surveillance

Gene Expression Regulation, Neoplastic

Inflammation

Tumor Suppressor Protein p53

Class I Phosphatidylinositol 3-Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 41152656
DOI: 10.1007/s10238-025-01889-4
PMCID: PMC12568875

Genes

FLT3LG
PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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