Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SF3B1 mutation accelerates the development of CLL via activation of the mTOR pathway.

JCI insight - 9 Sept 2025

Zhang Bo, Iyer Prajish, Jin Meiling, Ten Hacken Elisa, Cartun Zachary J, Hart Kevyn L, Fernandez Mike, Stevenson Kristen, Rassenti Laura, Ghia Emanuela M, Kipps Thomas J, Neuberg Donna, Carrasco Ruben, Chan Wing C, Song Joo Y, Hu Yu, Wu Catherine J, Wang Lili

Abstract excerpt

RNA splicing factor SF3B1 is one of the most recurrently mutated genes in chronic lymphocytic leukemia (CLL) and frequently co-occurs with chromosome 13q deletion [del(13q)]. This combination is associated with poor prognosis in CLL, suggesting these lesions increase CLL aggressiveness. While del(13q) in murine B cells (minimal deleted region of 13q14 includes DLEU1, DLEU2, and miR15a-16-1; Mdr mice), but not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Deletion

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to NFATC Transcription Factors

Share to Phosphoproteins

Share to RNA Splicing Factors

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 40694421
DOI: 10.1172/jci.insight.184280
PMCID: PMC12487679

Genes

SF3B1
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SF3B1 mutation accelerates the development of CLL via activation of the mTOR pathway.PMID 40694421Read ↗

Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.Semantic proximity Read ↗

SF3B1 and IGHV gene mutation status predict poor prognosis in Japanese CLL patients.Semantic proximity Read ↗

SF3B1 mutations in chronic lymphocytic leukemia.Semantic proximity Read ↗

Mutant SF3B1 promotes AKT- and NF-κB-driven mammary tumorigenesis.Semantic proximity Read ↗

SF3B1 mutation-mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia.Semantic proximity Read ↗

New boys in town: prognostic role of SF3B1, NOTCH1 and other cryptic alterations in chronic lymphocytic leukemia and how it works.Semantic proximity Read ↗

Studying the connection between SF3B1 and four types of cancer by analyzing networks constructed based on published research.Semantic proximity Read ↗

SF3B1 mutation and ATM deletion codrive leukemogenesis via centromeric R-loop dysregulation.Semantic proximity Read ↗

Dysregulated Spliceosome Activity Involves Increased Intron Retention Plus Upregulation and Phosphorylation of SF3B1 in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

SF3B1 Mutations Are Associated with Resistance to Non-Genotoxic MDM2 Inhibition in Chronic Lymphocytic Leukemia.Semantic proximity Read ↗

mTORC1 activity is essential for disease progression in chronic lymphocytic leukemiaSemantic proximity Read ↗

Understanding CLL biology through mouse models of human genetics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.