Article
Mutant SF3B1 promotes AKT- and NF-κB-driven mammary tumorigenesis.
The Journal of clinical investigation - 4 Jan 2021
Liu Bo, Liu Zhaoqi, Chen Sisi, Ki Michelle, Erickson Caroline, Reis-Filho Jorge S, Durham Benjamin H, Chang Qing, de Stanchina Elisa, Sun Yiwei, Rabadan Raul, Abdel-Wahab Omar, Chandarlapaty Sarat
Abstract excerpt
Mutations in the core RNA splicing factor SF3B1 are prevalent in leukemias and uveal melanoma, but hotspot SF3B1 mutations are also seen in epithelial malignancies such as breast cancer. Although hotspot mutations in SF3B1 alter hematopoietic differentiation, whether SF3B1 mutations contribute to epithelial cancer development and progression is unknown. Here, we identify that SF3B1 mutations in mammary epithelial...
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