Article
SF3B1 mutation and ATM deletion codrive leukemogenesis via centromeric R-loop dysregulation.
The Journal of clinical investigation - 1 Sept 2023
Cusan Martina, Shen Haifeng, Zhang Bo, Liao Aijun, Yang Lu, Jin Meiling, Fernandez Mike, Iyer Prajish, Wu Yiming, Hart Kevyn, Gutierrez Catherine, Nik Sara, Pruett-Miller Shondra M, Stark Jeremy, Obeng Esther A, Bowman Teresa V, Wu Catherine J, Lin Ren-Jang, Wang Lili
Abstract excerpt
RNA splicing factor SF3B1 is recurrently mutated in various cancers, particularly in hematologic malignancies. We previously reported that coexpression of Sf3b1 mutation and Atm deletion in B cells, but not either lesion alone, leads to the onset of chronic lymphocytic leukemia (CLL) with CLL cells harboring chromosome amplification. However, the exact role of Sf3b1 mutation and Atm deletion in chromosomal...
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