Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.

doi:10.1016/j.ccell.2016.10.005

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Article

Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.

Cancer cell - 14 Nov 2016

Wang Lili, Brooks Angela N, Fan Jean, Wan Youzhong, Gambe Rutendo, Li Shuqiang, Hergert Sarah, Yin Shanye, Freeman Samuel S, Levin Joshua Z, Fan Lin, Seiler Michael, Buonamici Silvia, Smith Peter G, Chau Kevin F, Cibulskis Carrie L, Zhang Wandi, Rassenti Laura Z, Ghia Emanuela M, Kipps Thomas J, Fernandes Stacey, Bloch Donald B, Kotliar Dylan, Landau Dan A, Shukla Sachet A, Aster Jon C, Reed Robin, DeLuca David S, Brown Jennifer R, Neuberg Donna, Getz Gad, Livak Kenneth J, Meyerson Matthew M, Kharchenko Peter V, Wu Catherine J

Abstract excerpt

Mutations in SF3B1, which encodes a spliceosome component, are associated with poor outcome in chronic lymphocytic leukemia (CLL), but how these contribute to CLL progression remains poorly understood. We undertook a transcriptomic characterization of primary human CLL cells to identify transcripts and pathways affected by SF3B1 mutation. Splicing alterations, identified in the analysis of bulk cells, were...

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Identifiers

PMID: 27818134
DOI: 10.1016/j.ccell.2016.10.005
PMCID: PMC5127278

Genes

DVL2
KLF8
TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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