Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Understanding CLL biology through mouse models of human genetics.

Blood - 23 Dec 2021

Ten Hacken Elisa, Wu Catherine J

Abstract excerpt

Rapid advances in large-scale next-generation sequencing studies of human samples have progressively defined the highly heterogeneous genetic landscape of chronic lymphocytic leukemia (CLL). At the same time, the numerous challenges posed by the difficulties in rapid manipulation of primary B cells and the paucity of CLL cell lines have limited the ability to interrogate the function of the discovered putative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Neoplastic
Share to Genomics
Share to Human Genetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Mice, Transgenic

Share to Neoplasm Transplantation

Share to Neoplasms, Experimental

Source

Open in PubMed Open full text

Identifiers

PMID: 34940815
DOI: 10.1182/blood.2021011993
PMCID: PMC8703365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Understanding CLL biology through mouse models of human genetics.PMID 34940815Read ↗

Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy.Semantic proximity Read ↗

Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease developmentSemantic proximity Read ↗

In Vivo Modeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic VulnerabilitiesSemantic proximity Read ↗

Human B Lymphomas Reveal Their Secrets Through Genetic Mouse Models.Semantic proximity Read ↗

Mouse Models in the Study of Mature B-Cell Malignancies.Semantic proximity Read ↗

Mouse Models of Germinal Center Derived B-Cell Lymphomas.Semantic proximity Read ↗

Lessons learned from the Eµ-TCL1 mouse model of CLLSemantic proximity Read ↗

Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance.Semantic proximity Read ↗

Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse linesSemantic proximity Read ↗

Richter syndrome: Novel insights into the biology of transformationSemantic proximity Read ↗

The B-cell receptor signaling pathway as a therapeutic target in CLLSemantic proximity Read ↗

Mice Overexpressing Wild Type RRAS2: A Novel Preclinical Model for Testing Anti-Chronic Lymphocytic Leukemia TherapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.