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Article

SF3B1 mutations in chronic lymphocytic leukemia.

Blood - 6 Jun 2013

Wan Youzhong, Wu Catherine J

Abstract excerpt

SF3B1 is a critical component of the splicing machinery, which catalyzes the removal of introns from precursor messenger RNA (mRNA). Next-generation sequencing studies have identified mutations in SF3B1 in chronic lymphocytic leukemia (CLL) at high frequency. In CLL, SF3B1 mutation is associated with more aggressive disease and shorter survival, and recent studies suggest that it can be incorporated into...

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Share to Chronic Lymphocytic Leukemia Research
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Share to Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ribonucleoprotein, U2 Small Nuclear

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Source

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Identifiers

PMID: 23568491
DOI: 10.1182/blood-2013-02-427641
PMCID: PMC3674664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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