Article
SF3B1 and IGHV gene mutation status predict poor prognosis in Japanese CLL patients.
International journal of hematology - 1 Feb 2016
Mitsui Takeki, Koiso Hiromi, Nakahashi Hirotaka, Saitoh Akio, Shimizu Hiroaki, Ishizaki Takuma, Ogawa Yoshiyuki, Takizawa Makiko, Yokohama Akihiko, Saitoh Takayuki, Jinbo Takahiro, Ogura Hidemi, Handa Hiroshi, Sawamura Morio, Sakura Tohru, Karasawa Masamitsu, Murakami Hirokazu, Nojima Yoshihisa, Tsukamoto Norifumi
Abstract excerpt
The incidence of chronic lymphocytic leukemia (CLL) is low in Japan. The clinical course ranges from very indolent to rapidly progressive. Recently, several reports have indicated that mutation of the splicing factor 3b, subunit 1 (SF3B1) gene in CLL is predictive of a poor prognosis. Here, we investigated the SF3B1 mutational status of Japanese CLL patients and clarified the association between SF3B1 mutational...
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