Article

mTORC1 activity is essential for disease progression in chronic lymphocytic leukemia

2022-04-20

Abstract excerpt

The precise role of mechanistic target of rapamycin complex 1 (mTORC1) during chronic lymphocytic leukemia (CLL) pathogenesis remains to be elucidated. Targeted deletion of mTORC1 component Raptor in adult mice reveals that mTORC1 function is essential for initiation and maintenance of CLL. Raptor -deficient bone marrow-derived PKCα-KR transduced haemopoietic progenitors failed to generate a CLL-like disease in...

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Literature Corpus work: 6e1acd56-f964-501d-8e9c-ed7b3b22ede6
DOI: 10.1101/2022.04.19.488778

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