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BIN1K358R suppresses glial response to plaques in mouse model of Alzheimer's disease

9 Mar 2024

Abstract excerpt

Abstract INTRODUCTION The BIN1 coding variant rs138047593 (K358R) is linked to Late‐Onset Alzheimer's Disease (LOAD) via targeted exome sequencing. METHODS To elucidate the functional consequences of this rare coding variant on brain amyloidosis and neuroinflammation, we generated BIN1K358R knock‐in mice using CRISPR/Cas9 technology. These mice were subsequently bred with 5xFAD transgenic mice, which serve as a...

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PMID: 38460121
DOI: 10.1002/alz.13767

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