Article

Detection of low-frequency mutations and removal of heat-induced artifactual mutations using Duplex Sequencing

2018-11-22

Abstract excerpt

We present a genome-wide comparative and comprehensive analysis of three different sequencing methods (conventional next generation sequencing (NGS), tag-based single strand sequencing (eg. SSCS), and Duplex Sequencing for investigating mitochondrial mutations in human breast epithelial cells. Duplex Sequencing produces a single strand consensus sequence (SSCS) and a duplex consensus sequence (DCS) analysis, respe...

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Literature Corpus work: a6396a47-e52a-5035-bcca-96f49c0e2765
DOI: 10.1101/474353

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